HomeTarlan Hazarpasha Mammadov sa sa


                                                      Tarlan Hazarpasha Mammadov                                         


Place of birth

Republic of Azerbaijan, Devechi district

Date of birth



Azerbaijan State University

Scientific degree

Doctor in biological sciences



Speciality code and title for PhD thesis

03.00.04, Biochemistry

“Purification and physicochemical properties of carbonic anhydrase from chickpea leaves”

Speciality code and title for doctoral thesis


Molecular Biology

“Characterization and expression analysis of PGPase and PEP-carboxylase genes and their catalytic subunits from unicellular green alga Chlamydomonas reinhardtii

Date of Election as a correspondent member and speciality


Molecular Biology

Total number of printed scientific publications


Number of scientific publications printed abroad


Number of papers published in journals indexed and abstracted in international databases


Number of patents and certificates of authorship


Staff training:

-          number of  PhD

-          number of Doctor of sciences


Basic scientific achievements

Several therapeutic targets, vaccines, therapeutic proteins, and inhibitors against COVID-19 coronavirus have been successfully synthesized and developed in plants.

For the first time, functionally active, full-length Pfs48 / 45 protein of Plasmodium Falciparum, one of the leading candidates for the malaria vaccine was successfully synthesized in plants using Endo H enzymatic technology. For the first time, a low-cost and highly immunogenic, stable and safe anthrax vaccine has been successfully synthesized in plants using Endo H enzymatic technology.

For the first time, a robust technology was developed by co-expression of target proteins of interest with bacterial Endo H enzyme, which enabled production of a number of valuable recombinant proteins (vaccines, therapeutic proteins, enzymes etc.) in plant leaves in non-glycosylated form without amino acid change in the resulting protein. Using this technology, vaccines for anthrax (for human and veterinary use) and malaria (for human use) have been successfully produced in green plant leaves.

For the first time, an expression system technology has been developed that provides glucose-free protein synthesis in eukaryotic systems, including the plant system. This technology has enabled the synthesis of very important and difficult-to-express complex protein antigens, vaccines and therapeutic proteins with high activity.

For the first time, the presence of glyco-proteins consisting of a residue of sialic acid combined with 1.4 galactose was discovered in green algae that fix carbon dioxide.

The enzyme phosphoglycolophosphatase, the main enzyme of photorespiration, was first obtained in the pure form from a eukaryotic organism, which allowed establishing the gene structure of the enzyme for the first time and to identify it in other organisms, including humans.

New genes and catalytic subunits of PEP-carboxylase, a key enzyme of C4 photosynthesis have been discovered in C. reinhardtii green alga.

The fastest gene synthesizing biotechnology in the world has been developed.

For the first time, the annealing time for the successful amplification of high guanine/cytosine-containing DNA was established.

For the first time, the enzyme carbonic anhydrase was purified from the Cicer arietinum plant, crystallized and examined under an electron microscope, and the enzyme was shown to have an octameric structure.

Names of scientific works

1. Tarlan Mamedov, Inanc Soylu, Gunay Mammadova, Gulnara Hasanova. Sequence Analysis and Amino Acid Variations of Structural Proteins Deduced From Novel Coronavirus SARS-CoV-2 Strains, Isolated in Different Countries. Preprint Article Version 1, doi: 10.20944/preprints202005.0026.v1

 2. Tarlan Mamedov, Kader Cicek, Kazutoyo Miura, Burcu Gulec, Ersin Akinci and Gunay Mammadova, Gulnara Hasanova. A Plant-Produced in vivo deglycosylated full-length Pfs48/45 as a Transmission-Blocking Vaccine Candidate against malaria. Sci Rep 2019. PMID 31285498

 3. Mamedov T, Musayeva I, Acsora R, Gun N, Gulec B, Mammadova G, Cicek K, Hasanova G.Engineering, and production of functionally active human Furin in N. benthamiana plant: In vivo post-translational processing of target proteins by Furin in plants. PLoS One. 2019 Mar 12;14(3):e0213438.doi:10.1371/journal.pone.0213438. eCollection 2019

4. Mamedov T, Cicek K, Gulec B, Ungor R, Hasanova G. In vivo production of non-glycosylated recombinant proteins in Nicotiana benthamiana plants by co-expression with Endo-β-N-acetylglucosaminidase H (Endo H) of Streptomyces plicatus. PLoS One. 2017 Aug 21;12(8):e0183589. doi: 10.1371/journal.pone.0183589. eCollection 2017.

 5. Production of Functionally Active and Immunogenic Non-Glycosylated Protective Antigen from Bacillus anthracis in Nicotiana benthamiana by Co-Expression with Peptide-N-Glycosidase F (PNGase F) of Flavobacterium meningosepticum. PLoS One. 2016, 11(4).

 6. Development of a Single-Replicon miniBYV Vector for Co-expression of Heterologous Proteins. Mol Biotechnol. 2015, 57(2), 101-10.

 7. In vivo deglycosylation of recombinant proteins in plants by co-expression with bacterial PNGase F. Bioengineered. 2013, 17, 4(5).

 8. Production of non-glycosylated recombinan proteins in Nicotiana benthamiana plants by co-expressing bacterial PNGase F. Plant Biotechnology Journal, 2012, 10(7), 773-82

 9. Co-Expression of Bacterial Enzyme PNGase F In Vivo Allows for Producing Recombinant Proteins of Interest in Plants in a Non-N-Glycosylated Form. ISB News Report, 2013, Jan., 5-8.

 10. Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activity. Human vaccine, 2011, 7, 191–198.

 11. Green algae Chlamydomonas reinhardtii possess endogenous sialylated N-glycans. FEBS Open Bio, 2011, 1, 15-22.

12. The effect of ultrasound stimulation on the gene and protein expression of chondrocytes seeded in chitosan scaffolds. J Tissue Eng Regen Med. 2011, 5(10), 815-822.

 13. Sequential co-immobilization of thrombomodulin and endothelial protein C receptor on polyurethane: activation of protein C.Acta Biomater. 2011 Jun;7(6):2508-17.

 14. Automated two-column purification of Iminobiotin and BrdU labeled PCR products for rapid cloning: application to genes synthesized by Polymerase Chain Assembly. J Chromatogr Sci. 2010, 48(2):120-124

 15. Gene synthesis by integrated polymerase chain assembly and PCR amplification using a high-speed thermocycler. J Microbiol Methods. 2009, 79(3):295-300.

 16. Gene synthesis by integrated polymerase chain assembly and PCR amplification using a high-speed thermocycler. J Microbiol Methods. 2009, 79(3):295-300.

 17. Molecular chaperon activity of tomato (Lycopersicon esculentum Mill.) Endoplasmic Reticulum-Located Small Heat-Shock Protein. Journal of Plant Research, 2008, 121: 235-243.

 18. A Fundamental Study of the PCR Amplification of GC-Rich DNA Templates. Comput. Biol. Chem., 2008, 32(6): 452-457.

 19.  Rational de novo gene synthesis by rapid polymerase chain assembly (PCA) and expression of endothelial protein-C and thrombin receptor genes. J Biotechnology, 2007, 131(4): 379-387.

 20. The two divergent PEP-carboxylase catalytic subunits in the green microalga Chlamydomonas reinhardtii respond reversibly to inorganic-N supply and co-exist in the high-molecular-mass, hetero-oligomeric Class-2 PEPC complex. FEBS Letters, 581: 4871-4876.

 21. Identification and expression analysis of two inorganic C-and N responsive genes encoding novel and distinct molecular forms of eukaryotic phosphoenolpyruvate carboxylase in the green microalga Chlamydomonas reinhardtii. The Plant Journal, 2005, 42: 832–843.

 22. Phosphoglycolate phosphatase gene and the mutation in phosphoglycolate phosphatase-deficient mutant (pgp1) of Chlamydomonas reinhardtii. Can. J. Botany, 83: 842-849.

 23. Characteristics and Sequence of Phosphoglycolate Phosphatase from an Eukaryotic Green Alga Chlamydomonas reinhardtii. J Biol. Chem., 2001, 276 (49): 45573-45579.

 24. A mutant of Chlamydomonas reinhardtii with Reduced Rate of Photorespiration. Plant Cell Physiol., 40(8): 792-799.

 25. Physicochemical properties and quaternary structure of carbonic anhydrase from Cicer arietinum leaves. Biochemistry, 51: 1785-1794.

 26. Quaternary structure of carbonic anhydrase from leaves of dicotyledonous plant Cicer arietinum. Doklady Academii Nauk, USSR Academy of Sciences 285(6): 1472-1475.

27. Subunit structure of carbonic anhydrase from leaves of chickpea. Doklady Academii Nauk, USSR Academy of Sciences, 280(6): 1466-1468.


Membership with international and foreign scientific organizations

Member of the American Society of Genetics

Member of the Japanese Society of Plant Physiologists

Member of the American Society of Plant Biologists

Member of the Turkish Biochemical Society

Pedagogical activity

2002-2009 Nebraska- Lincoln University, USA, Professor

2014- Akdeniz University, Turkey, Professor


Other activities

Editorial staff member: Journal of Plant Studies, International Journal of Plant Genomics.

Awards and prizes

1998: Award of Japan Science and Technology Agency (STA)

 1999: Award of Japan Science and Technology Agency (STA)

 2001: Award of Japan International Agricultural Center (JIRCAS) mükafatı

Place of work and its address

Akdeniz University, Department of Agriculture, Biotechnology, Dumlupınar Boulevard, 07058 Campus; Antalya, Turkey;

Institute of Molecular Biology and Biotechnologies of the National Academy of Sciences of Azerbaijan, AZ 1073, Izzat Nabiyev str.11 a



Office phone

(+90 242) 242 25 37


99 554 47 49


(+994 12) 436 90 05


(+90 242) 227 55 40