Tarlan Hazarpasha Mammadov
Place of birth | Republic of Azerbaijan, Devechi district | |
Date of birth | 02.05.1958 | |
Education | Azerbaijan State University | |
Scientific degree | Doctor in biological sciences | |
Title | Professor | |
Speciality code and title for PhD thesis | 03.00.04, Biochemistry “Purification and physicochemical properties of carbonic anhydrase from chickpea leaves” | |
Speciality code and title for doctoral thesis | 03.00.03 Molecular Biology “Characterization and expression analysis of PGPase and PEP-carboxylase genes and their catalytic subunits from unicellular green alga Chlamydomonas reinhardtii” | |
Date of Election as a correspondent member and speciality | 30.06.2014 Molecular Biology | |
Total number of printed scientific publications | 220 | |
Number of scientific publications printed abroad | 186 | |
Number of papers published in journals indexed and abstracted in international databases | 64 | |
Number of patents and certificates of authorship | 24 | |
Staff training: - number of PhD - number of Doctor of sciences | 18 | |
Basic scientific achievements | Several therapeutic targets, vaccines, therapeutic proteins, and inhibitors against COVID-19 coronavirus have been successfully synthesized and developed in plants. For the first time, functionally active, full-length Pfs48 / 45 protein of Plasmodium Falciparum, one of the leading candidates for the malaria vaccine was successfully synthesized in plants using Endo H enzymatic technology. For the first time, a low-cost and highly immunogenic, stable and safe anthrax vaccine has been successfully synthesized in plants using Endo H enzymatic technology. For the first time, a robust technology was developed by co-expression of target proteins of interest with bacterial Endo H enzyme, which enabled production of a number of valuable recombinant proteins (vaccines, therapeutic proteins, enzymes etc.) in plant leaves in non-glycosylated form without amino acid change in the resulting protein. Using this technology, vaccines for anthrax (for human and veterinary use) and malaria (for human use) have been successfully produced in green plant leaves. For the first time, an expression system technology has been developed that provides glucose-free protein synthesis in eukaryotic systems, including the plant system. This technology has enabled the synthesis of very important and difficult-to-express complex protein antigens, vaccines and therapeutic proteins with high activity. For the first time, the presence of glyco-proteins consisting of a residue of sialic acid combined with 1.4 galactose was discovered in green algae that fix carbon dioxide. The enzyme phosphoglycolophosphatase, the main enzyme of photorespiration, was first obtained in the pure form from a eukaryotic organism, which allowed establishing the gene structure of the enzyme for the first time and to identify it in other organisms, including humans. New genes and catalytic subunits of PEP-carboxylase, a key enzyme of C4 photosynthesis have been discovered in C. reinhardtii green alga. The fastest gene synthesizing biotechnology in the world has been developed. For the first time, the annealing time for the successful amplification of high guanine/cytosine-containing DNA was established. For the first time, the enzyme carbonic anhydrase was purified from the Cicer arietinum plant, crystallized and examined under an electron microscope, and the enzyme was shown to have an octameric structure. | |
Names of scientific works |
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Membership with international and foreign scientific organizations | Member of the American Society of Genetics Member of the Japanese Society of Plant Physiologists Member of the American Society of Plant Biologists Member of the Turkish Biochemical Society | |
Pedagogical activity | 2002-2009 Nebraska- Lincoln University, USA, Professor 2014- Akdeniz University, Turkey, Professor
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Other activities | Editorial staff member: Journal of Plant Studies, International Journal of Plant Genomics. | |
Awards and prizes | 1998: Award of Japan Science and Technology Agency (STA) 1999: Award of Japan Science and Technology Agency (STA) 2001: Award of Japan International Agricultural Center (JIRCAS) mükafatı | |
Place of work and its address | Akdeniz University, Department of Agriculture, Biotechnology, Dumlupınar Boulevard, 07058 Campus; Antalya, Turkey; Institute of Molecular Biology and Biotechnologies of the National Academy of Sciences of Azerbaijan, AZ 1073, Izzat Nabiyev str.11 a | |
Position | Professor | |
Office phone | (+90 242) 242 25 37 | |
Mobile | 99 554 47 49 | |
Home | (+994 12) 436 90 05 | |
Fax | (+90 242) 227 55 40 | |
| tmammedov@gmail.com |