Karim Guli Gasimov

Place of Birth:

Saatli of Azerbaijan Republic

Date of Birth:

30 November, 1958

Education:

Azerbaijan (present Baku) State University, faculty of biology

Scientific degree:

Doctor of Biological Sciences

Academic rank:

Specialty code and title for PhD thesis:

2406.02 – “Biochemistry”

“The regulation of cAMP phosfodiesteraze activity by red light and calmoduline in maize seedlings”

Specialty code and title for doctoral thesis:

2415.01 – “Molecular biology”

Molecular-Genetic characteristics of signal transduction in eukaryotes: G-proteins and JOINTLES-1transcription factor.

Total number of scientific publications:

63

Number of scientific publications printed abroad:

 48

Number of papers  published in journals indexed and abstracted in international databases:

 26

Certificates of authorship and number of patents:

Staff training:

-          Number of PhDs

-          Number of Doctors

Currently I am supervising 

 3 PhD student

1 Dr. of Sciences

Key scientific achievements:

1. The involvement of cAMP and cGMP systems in plant photosignal transduction. It was shown that both cyclic Nucleotide related enzymes ─ cyclases and phosphodiesterases strongly react the effect of moniochromatic red (660 nm) and far-red (730 nm) light.

2. Theo study G-protein linked signal transduction in animal organism in particular in phototransduction in vertebrate visual cascade. The role of GPR proteins as nucleotide exchange factors or as GDP dissociation inhibitors for Ga have been studied. We investigated the modulation of the GDP/GTP exchange of Gia₁, Goa, and Gsa by proteins containing GPR motifs to elucidate the mechanisms of GPR protein function.

3. The study visual cascade GPCR Rhodopsin residues responsible for G-protein transducin activation. It was found that three cytoplasmic loops in the G protein-coupled receptor rhodopsin, C2, C3, and C4 (H8), have been implicated as key sites for binding and activation of the visual G protein transducin.

4. Transcriptional regulation of plant differentiation upon development. The role of MADS domain transcription factor JOINTLESS in the abscission zone formation in tomato flowers and fruit were studied.

5. Transcriptional regulation of plant responces to environmental abiotic stresses. The WRKY transcription factors superfamily members involvement in plant responses to abiotic stresses, such as elevated salt and water deficit were studied. It was shown that the tomato plant WRKY33 transcription factor is a major factor that regulates the tomato plant tolerance to abiotic factor like water deficit and high salinity.

6. Investigation of the structural and functional domains of EGFR and HER2 receptors, representatives of the ErbB subfamily, which play a critical role in the formation of malignant carcinoma-type tumors (lung and breast), and the study of the fatal properties caused by the changes or mutations in these receptors.

Titles of publications:

1.    Azad Abdurahimov, Ilham Shahmuradov, Karim Gasimov. Subtle mechanisms of the visual cascade: searching for critical amino acid residues in signal transduction of the visual receptor rhodopsin. Journal of Life Sciences & Biomedicine, vol. 5 (78), No 1, p. 80-86 (2023)

2.    B. Bayramov, et al., . Association of miR-149 T>C and miR-196a2 C>T Polymorphisms with Colorectal Cancer Susceptibility: A Case-Control Study. Biomedicines (2023), 11(9), 2341-2346

3.    Z. Abaszade, K. Gasımov, I. Shahmuradov. Study of single nucleotide polymorphism in the encoding exons of the AGT gene of an arterial hypertension patient from Azerbaijan. Journal of Life Sciences & Biomedicine, 2024, v. 6(79), No 1, p. 11-21.

4.    I.A. Shahmuradov, et. al., Study of single nucleotide polymorphisms in the promoter regions of human AGT and AGTR1 genes. Azerbaijan Medical Journal (2025), 1 (1), 155-161

5.    Gasimov K. G. et al., Structural organization of HER2-HER3 heterodimers and an approach to the therapy of breast and lung cancers. Factors in experimental evolution of organisms, 2025, 36, 127-131

6.    T. Yusifov, et al.,  ABTS oxidat ion reaction as a model of cytochrome c-driven electron transfer. Ukr. Biochem. J. 2025, 97 (4), 43-51

7.    Abaszadeh Z.A. et al., Genotypic variations in the development of hypertension and other diseases of the cardiovascular system among persons of the Azerbaijan ethnos. Medical Science and Education of Ural, 2020, V. 21, № 2 (102) pp. 37-42

8.    Jafarov H.R, Azizov I.V., Abdurahimov A.R., Gasimov K.G. Expressions of SlWRKY33 and SlERF5 from tomato plants (Solanum lycopersicum L.) are induced by increased salinity. Nauchnie Gorizonti, 2018, №5(9), c. 158-169.

9.    Jafarov H.R, Gasimov K.G. Expression pattern of SlWRKY33 and SlERF5 in tomato plants under elevated salt concentration and water deficit. Фактори експериментальної еволюцiї организмiв, 2017, 20, 266-270

10.                 S. А. Karimli, G.E. Gasimova, M.A. Khanishova, I.V. Azizov, Y.M. Feyziyev, K.G. Gasimov Morpho-Physiological adaptation of Chestnut-Leaved Oak (Quercus Castanefolia) to Environmental Conditions. Proc. of Azerbaijan Nat. Acad., Biological Sciences. 2016,  V.71, No 1, p..97-102

11.                 Alakbarova,  GA, Jafarov, HR,  Gasimov, KG.  Tissue-specific expression of SlWRKY33 and SlRF5 transcription factors in tomato plant (Solanum lycopersicum L). Transactions of Institute of Botany Azerbaijan National Academy of Sciences, 2015, v.30, pp. 161-166.

12.           К.Г. Гасымов, Л.А. Наджафова Ген SlWRKY способствует толерантности растений тоиата к солевому и водному стрессам. Физиология Растений и Генетика, 2014, Т. 46, сс. 385-394.

13.           Gasimov K.G. GTP-binding proteins are potential messengers for photosygnal transduction in high plants. Proceedings of the 15^th International Congress on Photosynthesis, Advanced Topics in Science and Technology in China. Press and Springer, 2013, pp. 331-334.

Membership in national, international, and foreign scientific organizations:

Pedagogical performance:

2011-2015- Baku State University, faculity of biology

2014-2016 Lankaran State University.

2018-2020 ANAS, classes for Master students

2026 – classes for Master students in Bku state university, faculty of biology.

Other activities:

Place of work and its address:

Institute of Molecular Biology and Biotechnologies of the Ministry of Science and Education, 11 Izzet Nabiyev Street, Baku AZ1073, Azerbaijan

Position:

 Head of the Laboratory of Molecular Cell Biochemistry and Signal Transduction

Office phone:

+994-12-434-8345

Mobile phone:

+994-55-472-2258;  994-50-4242258

Home phone:

Fax:

E-mail:

 gasimovk@yahoo.com