| Taleh Nasib Yusifov | |
| Place of birth | Azerbaijan, Sheki |
| Date of birth | October 27, 1956 |
| Education | Faculty of Chemistry, Azerbaijan State University |
| Scientific degree | PhD in biology |
| Academic rank | Associate Professor |
| Speciality code and title for PhD thesis | 03.00.03 Molecular biology, Reducing the level of restriction imposed by plasmids |
| Total number of printed scientific publications | 61 |
| Number of scientific publications printed abroad | 59 |
| Number of papers published in journals indexed and abstracted in international databases | 60 |
| Number of patents and certificates of authorship |
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| Staff training: - number of PhD
| 1 |
| Key scientific achievements | Significant research has been conducted on the elucidation of protein structure and function using molecular biology, protein chemistry, biochemistry, crystallography, optical techniques, and solution-based biophysical methods. Studies have been carried out on biological sensors, protein–ligand interactions, and ligand-induced conformational changes in proteins, thereby contributing to the understanding of the transduction pathways of various signaling molecules. The physiological functions of large multimeric membrane-associated complexes and ion channels have been investigated. Recent studies have made it possible to determine the structural basis of ion channel activation mechanisms and to reveal new biological functions of these unique molecular systems. |
| Titles of publications | 1. Aliyeva A., Qudretova, F., Aliyeva N., Yusifov, T. (2026) Ion Channels and Regulatory Signals of Heme. European Journal of Biology, Q4. accepted. 2. Yusifov T., Qudratova F., Aliyeva A. (2025). Cytochrome C-like domain within the human BK channel. International Journal of Molecular Sciences, 26(15), 7053. Q1, Impact Factor: 4.9. 3. Gudratova F., Aliyeva A., Mahmudova S., Gasimov K., & Yusifov T. (2025). ABTS oxidation reaction as a model of cytochrome c-driven electron transfer. Ukrainian Biochemical Journal, 97(4), 43–51. Q4, Impact Factor: 1.45. 4. The Potassium Channels are an Important Target in Cancer Therapy.F Gudratova, A Aliyeva, S Mahmudova, K Gasimov, T Yusifov, Nature & Science, International Scientific Journal, 2025 / Volume: 7, Issue: 4 / 82-88 5. Yusifov T., Qudratova F., Aliyeva A. (2024). Role of bioelectrical signaling networks in tumor growth. American Journal of Biomedical and Life Sciences, 12(5), 83–9 6. Steccanella F., Savalli N, Yusifov T., Neely A., Olcese R.(2019). How Does the α2δ-1 Subunit Modulate Skeletal CaV1.1 Channels. Biophysical Journal, Vol. 116, p113a 7. Angelini M., Savalli N., Yusifov T., Olcese R. (2019). Skeletal γ1 Subunit Modulation of Human CaV1. 1 and CaV1. 2 Channels. Biophysical Journal, Vol. 116, p112-113a 8. 3. Yusifov T., Savalli N., Pantazis A., Heinemann S., Hoshi T. Olcese R. (2017). Carbon Monoxide May Regulate BK slo1 Channel Activity by Partially Disrupting Heme Coordination. Biophysical Journal, Vol. 112, p112a 9. Savalli N., Angelini M., Pantazis A., Yusifov T., Neely A., Olcese R. (2016). Eminence of VSD I in the Voltage-Dependent Inactivation of the Human CaV1.2 Channel. Biophysical Journal Vol.110, p444a 10. Yusifov T., Savalli N., Heinemann S, Hoshi T., Olcese R. (2015). The Heme Bound Human BK Channel Gating Ring is a CO Sensor, Biophysical Journal, Vol. 108, 122a. 11. Yusifov T., Savalli N., Park S.,Pantazis A., Olcese R. (2015). The Role of Met-691 in Heme-Dependent Regulation Supports the Presence of a Cytochrome-C-like Structure in Human BK Channels. Biophysical Journal, Vol.8 12. Yusifov T., Savalli N., Pantazis, A., Olcese R. (2014) Enzymatic Activity of the Human BK Channel: A Function Beyond Electrical Signaling, Biophysical Journal, Vol. 106, Issue 2, p535a 13. Yusifov T., Savalli N., Madhvani R., Gandhi Ch., Olcese R. (2014). The Human Bk Channel Encompasses a Cytochrome C-like Structure Within Its Intracellular Gating Ring Domain. 14. Yusifov T., Gandhi Ch., Pantazis, A., Olcese R. (2013). Structural Studies of the Apo and Ca2+-Bound States of the Human BK (SLO1) Channel Gating Ring in Solution. Biophysical Journal, Vol. 104, Issue 2, p473a 15. Yusifov T ., Gandhi Ch., Pantazis, A., Olcese R.(2013). Structural Studies of the Apo and Ca2+-Bound States of the Human BK (SLO1) Channel Gating Ring in Solution. Biophysical Journal, Vol. 104, Issue 2, p473a 16. Yusifov T., Savalli N., and Olcese, R. (2013). Carbon Monoxide Sensing Properties of the Human BK Channel Gating Ring. 17. Yusifov T ., Javaherian, AD., Heinemann SH., Hoshi T., Olcese R.(2012). Evidence for Lipid-Induced Structural Rearrangements in the Human BK (Slo1) Channel Gating Ring. Biophysical Journal, Vol. 102, p688a 18. Yusifov T., Javaherian, AD. Heinemann, SH., Hoshi, T., Olcese R. (2012). Calcium and Heme Induce Distinct Conformational States of the Human BK (Slo1) Channel Gating Ring. Biophysical Journal, Vol. 102, p687a– 19. Savalli N., Pantazis A., Yusifov T., Sigg D., and Olcese R. (2012). The contribution of RCK domains to human BK channel allosteric activation. J Biol. Chem., 287(26):21741-50 20. Yusifov T., Javaherian, AD., Pantazis A., Gandhi Ch. Olcese, R. (2011). Structural & Functional Analysis of the Human BK Channel Gating Ring and its components, RCK1 & RCK2, American Society of Anesthesiologists, Annual Meeting Papers 21. Yusifov T., Javaherian AD, Gandhi Ch. Olcese, R. (2011). On the Properties of the RCK1 Domain of the Human BK (SLO1) Channel. Biophysical Journal, Vol. 100, Issue 3, p581a 22. Yusifov T., Javaherian, AD, Pantazis, A., Gandhi Ch., Heinemann, SH.,Hoshi, T., Olcese R. (2011). Heme-Driven Conformational Changes in the Human Slo1 BKCa Channel Gating Ring. Biophysical Journal, Vol. 98 Issue 3, p126a 23. Javaherian AD., Yusifov T., Pantazis A., Franklin S., Gandhi Ch., Olcese, R. (2011). Metal-driven Operation of the Human Large-conductance Voltage- and Ca2+-dependent Potassium Channel (BK) Gating Ring Apparatus. J Biol Chem., 286(23): 20701- 19 24. Yusifov T., Javaherian AD., Pantazis A., Gandhi Ch., Olcese R. (2011) The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements. J Gen. Physiol. 136: 189–202 25. Javaherian, AD, Yusifov T., Nicole D., Gandhi, Ch., Olcese R. (2010). The purified BKca Gating Ring binds Ca2+ /Mg 2+, and undergoes a structural change, reflecting the molecular underpinnings of channel activation. American Society of Anesthesiologists, Annual Meeting Papers 26. Yusifov T., Javaherian AD., Hou S., Hoshi T., Olcese R. (2010). Heme Induced Structural Rearrangements in the Human BK Channel Intracellular C-Terminus. American Society of Anesthesiologists, Annual Meeting Papers 27. Yusifov T., Javaherian, AD, Gandhi Ch., Olcese, R. (2009). The Role of Aspartates 362/367 in the Ca 2+ Sensitivity of Human BKCa Channels. American Society of Anesthesiologists, Annual Meeting papers 28. Javaherian, AD., Yusifov T., Nicole D., Gandhi Ch., Olcese, R. (2009). The Intracellular C-Terminus of the Human BKCa Channel Is a Ca 2+ -Binding Tetrameric Domain Structural and Functional Analysis of the Purified Cytosolic C-Terminus of the Human BK Channel. Biophysical Journal, Vol. 96, Issue 3, p481a 29. Javaherian AD., Yusifov T., Nicole D., Gandhi Ch., Olcese, R. (2009). Structural and Functional Analysis of the Purified Cytosolic C- Terminus of the Human BK Channel. Biophysical Journal, Vol. 96, Issue 3, p481a 30. Javaherian AD., Yusifov T., Nicole D., Gandhi Ch., Olcese, R. (2009). Structural and Functional Analysis of the Purified Cytosolic C- Terminus of the Human BK Channel. Biophysical Journal, Vol. 96, Issue 3, p481a 31. Yusifov T., Javaherian AD., Nicole D., Gandhi Ch., Olcese, R. (2009). Calcium Sensing Properties of the RCK1 Domain of the Human BK Channel: Effects of the D362/367A Mutation. Biophysical Journal, 32. Yusifov T., Abduragimov AR., Gasymov OK., Glasgow BJ. (2008). Tear lipocalin is the major endonuclease in tears. Mol.Vis. 14:180-188. 33. Yusifov T., Savalli N., Ottolia M., and Olcese R. (2008). The RCK2 Domain of the human BKCa channel is calcium sensor. PNAS, 105: 376-381 34. Gasymov OK, Abduragimov AR, Prasher P, Yusifov TN, Glasgow BJ. Tear lipocalin: evidence for a scavenging function to remove lipids from the human corneal surface. Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3589-96. doi: 10.1167/iovs.05-0569. PMID: 16186338; PMCID: PMC1618769. 35. Gasymov OK., Abduragimov AR., Yusifov T., Glasgow BJ. (2004). Inter-strand loops CD and EF act as pH-dependent gates to regulate fatty acid ligand binding in tear lipocalin. Biochemistry 43(40): 12894-904. 36. Glasgow BJ, Gasymov OK, Abduragimov AR, Yusifov TN, Altenbach C, Hubbell WL. Side chain mobility and ligand interactions of the G strand of tear lipocalins by site-directed spin labeling. Biochemistry. 1999 Oct 12;38(41):13707-16. doi: 10.1021/bi9913449. PMID: 10521278. 37. Gasymov OK., Abduragimov AP., Gasimov EO., Yusifov T., Dooley AK., Glasgow BJ. (2004). Tear lipocalin: potential for selective delivery of rifampin. Biochim. Biophys. Acta. 1688(2): 102-11. 38. Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ. Resolving near-ultraviolet circular dichroism spectra of single trp mutants in tear lipocalin. Anal Biochem. 2003 Jul 15;318(2):300-8. doi: 10.1016/s0003-2697(03)00215-x. PMID: 12814635. 39. Gasymov OK., Abduragimov AR., Yusifov T., Glasgow BJ. (2003). Resolving near-ultraviolet circular dichroism spectra of single Trp mutants. Anal Biochem. 318(2): 300-8. 40. Glasgow BJ, Abduragimov AR, Gasymov OK, Yusifov TN. Tear lipocalin: structure, function and molecular mechanisms of action. Adv Exp Med Biol. 2002;506(Pt A):555-65. doi: 10.1007/978-1-4615-0717-8_78. PMID: 12613960. 41. Glasgow BJ, Abduragimov AR, Gassymov OK, Faull KF, Yusifov TN, Lehrer RI. Characterization of a lipophilin in rabbit tears. Adv Exp Med Biol. 2002;506(Pt A):573-80. doi: 10.1007/978-1-4615-0717-8_80. PMID: 12613962. 42. Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ. Relaxation of beta-structure in tear lipocalin and enhancement of retinoid binding. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3165-73. PMID: 12356820. 43. Abduragimov AR, Gasymov OK, Yusifov TN, Glasgow BJ. Functional cavity dimensions of tear lipocalin. Curr Eye Res. 2000 Oct;21(4):824-32. doi: 10.1076/ceyr.21.4.824.5551. PMID: 11120574. 44. Glasgow BJ, Abduragimov AR, Gassymov OK, Yusifov TN, Ruth EC, Faull KF. Vitamin E associated with the lipocalin fraction of human tears. Adv Exp Med Biol. 2002;506(Pt A):567-72. doi: 10.1007/978-1-4615-0717-8_79. PMID: 12613961. 45. Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ. RET and anisotropy measurements establish the proximity of the conserved Trp17 to Ile98 and Phe99 of tear lipocalin. Biochemistry. 2002 Jul 16;41(28):8837-48. doi: 10.1021/bi0121003. PMID: 12102626. 46. Yusifov T., Abduragimov AR., Gasymov OK., Glasgow BJ. (2000). Endonuclease Activity in Lipocalins. Biochem. J. 347(3): 815-819 47. Abduragimov AR, Gasymov OK, Yusifov TN, Glasgow BJ. Functional cavity dimensions of tear lipocalin. Curr Eye Res. 2000 Oct;21(4):824-32. doi: 10.1076/ceyr.21.4.824.5551. PMID: 11120574. 48. Glasgow BJ, Marshall G, Gasymov OK, Abduragimov AR, Yusifov TN, Knobler CM. Tear lipocalins: potential lipid scavengers for the corneal surface. Invest Ophthalmol Vis Sci. 1999 Dec;40(13):3100-7. PMID: 10586930. 49. Zhao C, Nguyen T, Yusifov T, Glasgow BJ, Lehrer RI. Lipophilins: human peptides homologous to rat prostatein. Biochem Biophys Res Commun. 1999 Mar 5;256(1):147-55. doi: 10.1006/bbrc.1999.0274. PMID: 10066439. 50. Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ. Interaction of tear lipocalin with lysozyme and lactoferrin. Biochem Biophys Res Commun. 1999 Nov 19;265(2):322-5. doi: 10.1006/bbrc.1999.1668. PMID: 10558865. 51. Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ. Binding studies of tear lipocalin: the role of the conserved tryptophan in maintaining structure, stability and ligand affinity. Biochim Biophys Acta. 1999 Aug 17;1433(1-2):307-20. doi: 10.1016/s0167-4838(99)00133-8. PMID: 10515687. 52. Glasgow BJ, Gasymov OK, Abduragimov AR, Yusifov TN, Altenbach C, Hubbell WL. Side chain mobility and ligand interactions of the G strand of tear lipocalins by site-directed spin labeling. Biochemistry. 1999 Oct 12;38(41):13707-16. doi: 10.1021/bi9913449. PMID: 10521278. 53. Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ. Structural changes in human tear lipocalins associated with lipid binding. Biochim Biophys Acta. 1998 Jul 28;1386(1):145-56. doi: 10.1016/s0167-4838(98)00092-2. PMID: 9675263. 54. Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ. (1997). Solution structure by site directed tryptophan fluorescence in tear lipocalin. Biophys.Res.Commun., 239; 191 55. Yusifov TN, Zavilgelskii GB, Delver EP, Belogurov AA (1987). Alleviation of K-restriction in the presence of plasmid pKM101 ard+. II. Cloning of the ard gene. Molekulyarnaya Biologiya, 21: 847-852 56. Aliyev DA, Muradov AZ, Yusifov TN, Mamedov ACH, Albiov GV. (1986). Studying the structural organization of chloroplast DNA 1. Obtaining the genomic library of spinach chloroplast DNA. Izvestiya Akademii Nauk Azerbaidzhanskoi SSR Seriya Biologicheskikh Nauk, 4: 3-7 57. Belogurov AA, Yusifov TN, Zavilgelskii GB, Kotova VY. (1985). The novel gene(s) Ard of plasmid pKM101: Alleviation of EcoK-restriction. Molecular General Genetics 198:509-13 58. Zavilgelskii GB, Mershavka VY, Yusifov TN, Belogurov AA. (1984). Plasmid pKM101 ard+ mediated alleviation of K-restriction of bacteriophage λ; I. General characteristics and localization of the ard gene. Molekulyarnaya Biologiya, 18: 1590-1597. 59. Braga EA, Yussifov TN, Nosikov V V. Structural organization of rat ribosomal DNAs. Gene. 1982 Dec;20(2):145–56.
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| Place of work and its address | Institute of Molecular Biology, AZ1141, Baku, Izzet Nabiyev Street 11 |
| Position | Leading researcher |
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| Mobile | 055 638 49 49 |
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