| Staff: | senior researcher Fidan Rahim Huseynova researcher Zarintaj Rasim Shatirova researcher Lala Ahmed Akhundova junior researcher Gulmira Rizvan Alibayova junior researcher Aygun Vagifovna Suleymanova senior laboratory assistant Shalala Hilal Majdova |
| Research directions of the laboratory: | - Large-scale molecular-genetic study of the Azerbaijani population genefund with various markers (with markers that allow detection of autosomal, sex (X- and Y-STR), mitochondrial DNA point (SNP) mutations, etc.);
- Molecular-genetic research of archaeo-biological materials (human, fauna and flora remains) obtained from important historical human settlements, mass graves and other archaeological excavations in the territory of Azerbaijan; Research on genetic and non-hereditary autoimmune and chronic diseases (e.g. diabetes, hypertension, cardiovascular, lung, muscle dysplasias, oncological, neuro-degenerative and rare genetic diseases) widespread in Azerbaijan at the population level using known markers as well as classical molecular biological, modern genome-wide association (GWA) and candidate gene approaches (CGA).
- Development of prenatal and postnatal diagnostic tests for timely diagnosis and prevention of diseases;
- Isolating and transferring the stem cells to culture from various human tissues and investigating the possibility of using them in regenerative medicine in the future.
|
| Main scientific achievements: | - Y-chromosome haplotypes of 225 Azerbaijani citizens living in Azerbaijan were obtained using the AmpFlSTR® Yfiler® PCR Amplification Kit consisting of 17 loci. The haplogroups of those individuals were determined by means of two different haplogroup predictors and a distribution map of haplogroups was drawn up.
Haplotype diversity results have been deposited in the local (http://imbb.az/uploads/AZE_Y_STR_Profiles_for_YHRD.pdf) and international databases (https://yhrd.org/YA00469) under the identification number YA00469; - For the first time, the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme gene in the Azerbaijani population was studied in 346 unrelated people of different age groups and working in different occupations. Məlum olmuşdur ki, aşkarlanan allellər arasında D alleli, genotiplər arasında isə İD genotipi üstünlük təşkil edir;
- During the study of the rs1544410 (A>G) polymorphism of the VDR gene, no statistically significant correlation was recorded between the risk of type I diabetes and the SNP mutation in the Azerbaijani population;
- For the first time in our population, the 3'ÚTR A→G (2758 A>G, (rs696)) polymorphism of the nuclear transcription factor inhibitor NF-κBIA (IκBα) gene expressed in B cells was studied, the frequencies of alleles and genotypes were calculated, and their correlative relationships with disease risk were investigated in patients with various types of cancer, both cancer and diabetes. In the group suffering from both cancer and diabetes, a statistically reliable correlation was determined between AG genotype (P=0.04), and dominant and overdominant models from genetic models (P=0.04 and P=0.039, respectively);
- It was found that insulin acts as a growth factor and after 25 hours, the pulp cell proliferation and gene expression of some osteogenic markers (Col1, RunX2, ALP, Osc, Mef2C) and the participants of the TGF b (transformation factor for beta) pathway such as Smad3, TSP1, and VEGF mRNA increase at the mRNA level.
|
