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The mechanism of a deadly and widespread infection has been revealed Jun 12, 2020 | 11:41 / Interesting information

Scientists at the University of Alberta in Canada have identified how the respiratory syncytial virus (RV) infects human cells, one of the most common and dangerous pathogens of respiratory infections. This infection poses a great danger to young people and children. There is no medicine or vaccine against it. The unique feature of the virus is that it stays in the cell for several hours before it penetrates. The main role in infection is played by the nucleolin, the cell receptor to which the virus binds, and then infects the cell. Typically nucleolin is located inside the cell. Scientists did not know what made it come to the surface. It was found that RSV first binds to another IGF1R receptor and PKC-zeta protein and signals inside the cell like a doorbell. In fact, the virus has developed normal cell functions for its own purposes. However, at the beginning of the development of the virus, the question arises as to whether it is related to nucleolin or IGF1R. Scientists will learn about this in future research. The authors hope that the study will help develop effective ways to treat the disease, which causes 200-200 thousand deaths worldwide each year.